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Research
My research focuses on studying mechanisms of the RNA modification N6-methyladenosine (m6A). Work is focused on two distinct experimental systems: the long noncoding RNA (lncRNA) HOTAIR in breast cancer, and morphological switching in the pathogenic yeast Candida albicans.
01
Importance of a single m6A site in lncRNA HOTAIR
We have discovered a single m6A site in HOTAIR that regulates its ability to interact with chromatin and mediate changes in gene expression that facilitate invasion and growth of cancer cells.
02
m6A mediates opaque-to-white switching in C. albicans
We have identified a role for the m6A methyltransferase, IME4, in mediating opaque-to-white phenotypic switching in C. albicans, a process known to regulate virulence in this pathogenic yeast.
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